A "snowclone" is a multi-use template into which many things can be substituted.  For instance:
- ___ is the new ___;
 - There are always more ___ in the ___;
 - Keep ___ and ___ ___;
 - Once a ___ always a ___;
 - Dude, where's my ___;
 - The new ___ on the ___;
 - You say ___, I say ___;
 - Yo Dawg, I herd you like ___, so I put a ___ in your ___ so you can ___ while you ___;
 
To help illustrate the idea, I did some meme frequency analysis on Theodosius Dobzhansky's famous snowclone:
Nothing in ___ makes sense except in the light of ___
The results:
- Nothing in biology makes sense except in the light of evolution (560,000)
 - Nothing in medicine makes sense, except in the light of evolution (20,200)
 - Nothing about protein structure classification makes sense except in the light of evolution (8,220)
 - Nothing in glycobiology makes sense except in the light of evolution (4,690)
 - Nothing in evolution makes sense except in the light of DNA (1,750)
 - Nothing in evolution makes sense except in the light of ecology (754)
 - Nothing in morality makes sense except in the light of evolution (337)
 - Nothing in biochemistry makes sense except in the light of evolution (124)
 - Nothing in psychology makes sense except in the light of evolution (119)
 - Nothing in economics makes sense except in the light of evolution (81)
 - Nothing in evolution makes sense except in the light of phylogeny (74)
 - Nothing in politics makes sense, except in the light of cultural evolution (55)
 - Nothing in human psyche and society makes sense except in the light of cultural evolution (10)
 - Nothing in evolution makes sense except in the light of genetics (9)
 - Nothing in Nazism makes sense except in the light of evolution (5)
 - Nothing in evolution makes sense except in the light of fitness landscapes (5)
 - Nothing about human cooperation makes sense except in the light of cultural evolution (3)
 - Nothing in physics makes sense except in the light of the big bang (3)
 - Nothing in economics makes sense except in the light of ecology (3)
 - Nothing in physics makes sense except in the light of information (2)
 - Nothing in biology (including psychology) makes sense except in the light of evolution (1)
 
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