The audio is not always 100% clear, but he provides an executive summary:
In this video, I explain why memes do not function as independent replicators the way DNA does. I propose that memetics is fundamentally flawed in that it fails to acknowledge that if bits of human culture do make copies of themselves inside our brains, the mutations that occur during the copying process of memes are manipulated by our brains so that memes end up evolving not for their own survival and reproduction, but for ours. Thus memes, unlike DNA, do not have a random mutation-generating mechanism, which is the basis for darwinian processes to apply.That argument seems easy to dismantle: random mutations are not part of Darwinism. Darwin knew little about mutation mechanisms. Random mutations came into evolutionary theory with NeoDarwinism around the 1940s. NeoDarwinism was a fusion of Darwinism with ideas from Mendel. However, Mendelian doctrines are very tied to DNA, and don't really apply to cultural evolution. NeoDarwinism makes a bad starting point there, and so most theorists go back to Darwin.
Evolutionary theory does't require random mutations. That's a simplifying assumption. The more usual requirements are often phrased as being "variation" and "selection". Of course, without random mutations, the theory makes weaker predictions - but that's a bit of a different issue. One does not reject a theory entirely just because it does not constrain expectations as much as some of its critics would like.
Of course some memetic enginnering results in memes that benefit humans. Similarly some genetic engineering results in plants and animals that benefit humans. Such engineering doesn't challenge evolutionary theory. Memetic and genetic engineering are part of evolution. If you have a theory of evolution that is incapable of coping with engineering, that's a pretty feeble theory of evolution.
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